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Q4 acquires Euroinvestor IR Solutions The PD-1/PD-L1 pathway that affords tumor immune evasion is an adaptive resistance mechanism in which PD-L1 expression is induced in the tumor microenvironment by IFNγ producing T cells . Poxvirus-based active immunotherapies induce infiltration of antigen-specific T cells to the tumor, which produce large amounts of IFNγ after encountering the cognate tumor-antigen . We investigated whether poxvirus-based active immunotherapies would increase PD-L1 expression in the tumor kryptovaluta microenvironments of transplantable solid tumor or experimental lung metastasis mouse models. Both the CT26-HER-2 and MC38-MUC1 murine tumor cell lines up-regulate PD-L1 in response to IFNγ in a dose-dependent manner . Mice were implanted with CT26-HER-2 tumor cells and treated with MVA-BN-HER2, anti-PD-1, and or anti-LAG-3 as indicated in the figure. Tumor free mice were re-challenged with CT26-WT cells not expressing HER-2 , 154 days after the original challenge...

Healing Water restoring ecosystems by healing natural water cycles I had never been truly inspired by mechanical displays, and fountain jets left me cold – but the charms of natural, flowing water never ceased to stir my imagination. Ashley McKinney, a Communications Specialist for the institute, says that Bartram and his team published a study which estimated that 28 percent of the world’s population, or 1.8 billion healing-water people, had used unsafe water in 2010. That estimate was one billion people more than the estimate by UNICEF and the World Health Organization. As activists across the globe celebrate World Water Day on Saturday, UNC’s The Water Institute is working on campus and internationally to help make safe water and sanitation a reality for all people. Given to plants, these minerals shorten the growing period, increase yield, reduce watering needs, increase drought and freeze resistance, plants produce more viable seeds, etc. Trials with chickens in Holland sugges...