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Q4 acquires Euroinvestor IR Solutions The PD-1/PD-L1 pathway that affords tumor immune evasion is an adaptive resistance mechanism in which PD-L1 expression is induced in the tumor microenvironment by IFNγ producing T cells . Poxvirus-based active immunotherapies induce infiltration of antigen-specific T cells to the tumor, which produce large amounts of IFNγ after encountering the cognate tumor-antigen . We investigated whether poxvirus-based active immunotherapies would increase PD-L1 expression in the tumor kryptovaluta microenvironments of transplantable solid tumor or experimental lung metastasis mouse models. Both the CT26-HER-2 and MC38-MUC1 murine tumor cell lines up-regulate PD-L1 in response to IFNγ in a dose-dependent manner . Mice were implanted with CT26-HER-2 tumor cells and treated with MVA-BN-HER2, anti-PD-1, and or anti-LAG-3 as indicated in the figure. Tumor free mice were re-challenged with CT26-WT cells not expressing HER-2 , 154 days after the original challenge...

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